Fix Premature Ejaculation with Dapoxetine
Having orgasm and ejaculating is a something that man can’t control properly, especially after a prolonged abstinence. Problem happens when the woman does not even try to understand it. Premature ejaculation (PE) is defined as a “persistent or recurrent onset of ejaculation with minimal sexual stimulation before, on, or shortly after penetration” and, of course, this is not the man’s desire.
Premature ejaculation is more than a sexual issue; it is a psychological condition, inducing distress and dissatisfaction in couple’s sexual relations. Recent investigations suggested that Premature ejaculation is tied to an impairment in serotonergic 5-hydroxytrptamine (5-HT) neurotransmission.
That’s the reason why all new premature ejaculation treatments target the 5-HT system. A recent trial made by Francisco Giuliano from Garches Frances investigated the efficacy of a new PE drug, dapoxetine. Dapoxetine hydrochloride is a short-lived selective serotonin reuptake inhibitor (SSRI) aiming the PE condition in a special.
Other most available SSRIs like paroxetine, fluoxetine and sertraline may increase ejaculatory latency time, but their effect occurs in several hours,. In the same time the maximal effect of dapoxetine occurs in just one hour. 50 % of dapoxetine is eliminated after 1.2 hours and after 24 hours only 5% of it may still be found in the cells, making it more effective and safer.
The two-placebo trial was made on over 2600 male subjects, and dapoxetine, 30 or 60 mg, was taken 1-3 hours before the sexual intercourse and the volunteers’ average age was 40.
65 % of the subjects had lifelong premature ejaculation and 35% had PE that emerged after a time of normal sexual function.
The duration of the sexual intercourse was linked to the dapoxetine dose: 0.9 – 1.75 minutes for placebo, 0.92 – 2.78 minutes for 30 mg of dapoxetine and 0.91 – 3.32 minutes for 60 mg of dapoxetine. The drug worked on the first dose, but also subsequent ones and the effect persisted during the 12-week trial.
Dapoxetine’s secondary effects were weak: just mild nausea (8.7 % for the 30 mg dose and 20.1 % for the 60 mg dose) and headache (5.9% for the 30 mg dose and 6.8% for the 60 mg dose). Discontinuation induced by adverse effects was of 4 % for 30 mg dose and 10 % for the 60 mg dose.
This investigation showed the efficacy of dapoxetine which is turning to be the best premature ejaculation treatment and gaining more popularity in the world. Needless to say that one can buy dapoxetine in our pharmacy and end premature ejaculation problem shortly.
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